HPSE2 — Heparanase 2 (inactive)
HPSE2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HPSE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ASPN+ Submucosal Fibroblast ECM production | ASPN, BCHE, CLEC14A, COL6A5, DIO2, FNDC1, HMCN1, HMCN2 +5 more | View in SCUBA |
| Smooth muscle cells | Telocyte/Fibroblast Contamination Cell contamination | ABI3BP, ADH1B, ASB2, BCHE, BMP4, C5orf66-AS1, CDCA7L, FENDRR +5 more | View in SCUBA |
About the gene
| Synonyms | HPA2, HPR2, UFS |
|---|---|
| Chromosome | 10: 98457077-99235862 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.