DPAGT1 — Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
DPAGT1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DPAGT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Central Carbon Metabolism Housekeeping | ACLY, ACO2, CBFB, CSK, DARS1, DLD, EMC1, GART +19 more | View in SCUBA |
About the gene
| Synonyms | ALG7, CDG-Ij, D11S366, DGPT, DPAGT, DPAGT2, GPT |
|---|---|
| Chromosome | 11: 119096025-119108331 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
UDP-N-acetylglucosamine--dolichyl-phosphate N- acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol- linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P- dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.