Central Carbon Metabolism
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 28 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 28 genes have a known function matching the annotation |
Why this annotation
Hub genes ACLY and HACD2 drive lipid/fatty acid synthesis; GPI and PFKL indicate glycolysis; GART supports purine biosynthesis; DARS1/RARS1 are aminoacyl-tRNA synthetases; UTP18 and PWP1 link to rRNA processing. All genes show weak membership and uniform expression across subsets, consistent with broadly expressed metabolic housekeeping. No strong single pathway dominates, but lipid and central carbon metabolism genes are most prominent.
Genes
ACLY, ACO2, CBFB, CSK, DARS1, DLD, DPAGT1, EMC1, GART, GPI, HACD2, KCTD9, KPNA3, LNPK, LRRC8D, MFSD14B, NNT, PFKL, PWP1, RARS1, RMDN1, RNPEP, RPE, RSU1, SLC39A6, SLF2, UTP18, VKORC1L1
Most correlated modules
- ER Morphology Stress · correlation 0.97
- Glycogen Metabolism · correlation 0.96
- ER Protein Quality Control · correlation 0.95
- ER Membrane Homeostasis · correlation 0.94
- Autophagy Vesicular Trafficking · correlation 0.94
- ER-Lysosome Trafficking · correlation 0.94
- Monocyte-Mac Iron Transport · correlation 0.94
- Ubiquitin-Proteasome System · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.