ACLY — ATP citrate lyase
ACLY belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACLY's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | ER Antigen Processing Protein processing & ER | ATL3, ATR, CANX, DCTN1, DDB1, ERAP1, FOXJ3, ITCH +9 more | |
| Goblet cells | Mucin O-Glycosylation Mucus production & secretion | ASPH, C9orf152, CKAP4, ESRP1, FABP2, IL13RA1, PLPP5, RAB2A +8 more | View in SCUBA |
| Macrophages | Central Carbon Metabolism Housekeeping | ACO2, CBFB, CSK, DARS1, DLD, DPAGT1, EMC1, GART +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | PI3K-Calcineurin Signaling TCR Signaling | BCL9L, CABIN1, CDK11A, LATS2, NBPF19, NUP210, PIK3CD, POM121C +2 more |
About the gene
| Synonyms | ACL, ATPCL, CLATP |
|---|---|
| Chromosome | 17: 41866917-41930542 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Citric acid cycle related proteins, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Lipid biosynthesis, Lipid metabolism |
Function
Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.