ACO2 — Aconitase 2
ACO2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACO2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Chylomicron lipid absorption Lipid metabolism | ALDOB, ANPEP, CNDP2, DGAT1, ENPEP, FABP2, MOGAT2, MTTP +3 more | View in SCUBA |
| Macrophages | Central Carbon Metabolism Housekeeping | ACLY, CBFB, CSK, DARS1, DLD, DPAGT1, EMC1, GART +19 more | View in SCUBA |
About the gene
| Synonyms | ACONM |
|---|---|
| Chromosome | 22: 41447830-41529273 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Citric acid cycle related proteins, Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Lyase |
| Biological process | Tricarboxylic acid cycle |
Function
Catalyzes the isomerization of citrate to isocitrate via cis- aconitate
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.