CSK — C-terminal Src kinase
CSK belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CSK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Protein/ER secretory machinery Protein processing & ER | ACTR2, ATP5IF1, ATP5ME, BAZ1B, CMC2, CNPY2, COMMD3, COPZ1 +16 more | View in SCUBA |
| CD8⁺ T cells | TCR Proximal Signaling TCR Signaling | CHMP2A, HCLS1, MAP2K2, MPG, NOP10, PRDX5, SRP14, ZNHIT1 | View in SCUBA |
| Gamma-delta T cells | T Cell Homeostasis Housekeeping | ATP6V0E1, CALHM2, CNPY2, CSTB, DAD1, FERMT3, GTF2H5, MYL12A +11 more | |
| Innate lymphoid cells | JAK-STAT Cytokine Signaling Inflammation | AASDHPPT, ARHGAP9, CHURC1, CIDEB, DCAF7, DENND2D, EDEM2, EIF4EBP2 +23 more | View in SCUBA |
| Macrophages | Central Carbon Metabolism Housekeeping | ACLY, ACO2, CBFB, DARS1, DLD, DPAGT1, EMC1, GART +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | Actin Cytoskeletal Dynamics Cytoskeletal | ACTB, ACTG1, CLIC1, CORO1A, CTSC, NHERF1, PPP1CA, RAC2 +2 more | |
| Natural Killer cells | NK TGF-β Regulation Immune regulation | AOAH, GIMAP5, NCR1, PPP1R18, PTPN6, PYCR2, SASH3, TGFBR2 +1 more | View in SCUBA |
About the gene
| Chromosome | 15: 74782080-74803197 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase, Tyrosine-protein kinase |
| Biological process | Adaptive immunity, Immunity |
Function
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.