DARS1 — Aspartyl-tRNA synthetase 1
DARS1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DARS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial RNA Processing Mitochondrial & OxPhos | ABR, DENND1C, GTDC1, MRPS30, PDCD4, PMPCB, POLG, PRKD2 +11 more | |
| Innate lymphoid cells | Septin Cytoskeleton Cytoskeleton & motility | ATP6V0C, C17orf49, CIAO2A, COX16, DDOST, GET3, H2AC6, H3-3B +18 more | View in SCUBA |
| Macrophages | Central Carbon Metabolism Housekeeping | ACLY, ACO2, CBFB, CSK, DLD, DPAGT1, EMC1, GART +19 more | View in SCUBA |
About the gene
| Synonyms | DARS |
|---|---|
| Chromosome | 2: 135905881-135986100 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Aminoacyl-tRNA synthetase, Ligase |
| Biological process | Protein biosynthesis |
Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.