DUSP14 — Dual specificity phosphatase 14
DUSP14 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DUSP14's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell Coinhibition Immune regulation | BTLA, CASD1, CFAP36, FCHSD2, HIVEP2, IFNGR2, KLF7, NAP1L2 +7 more | View in SCUBA |
About the gene
| Synonyms | MKP-L, MKP6 |
|---|---|
| Chromosome | 17: 37489891-37513501 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Plays a negative role in TCR signaling by dephosphorylating MAP3K7 adapter TAB1 leading to its inactivation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.