HIVEP2 — HIVEP zinc finger 2

HIVEP2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

HIVEP2's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	T cell Coinhibition Immune regulation	BTLA, CASD1, CFAP36, DUSP14, FCHSD2, IFNGR2, KLF7, NAP1L2 +7 more	View in SCUBA
Lymphatic endothelial	NF-κB Innate Signaling Inflammation	AKAP13, B4GALT5, BACH1, CHD2, CNST, DENND5A, HIVEP1, IRAK2 +11 more	View in SCUBA
Macrophages	MAPK Stress Kinase Inflammatory	ARHGAP26, BRAF, BTBD9, CRY1, CYTH3, EIF2AK3, ESYT2, EXT1 +12 more	View in SCUBA
Mucosal-associated invariant T cell	SWI/SNF Chromatin Remodeling DNA/chromatin regulation	ABTB3, AOAH, ARID1B, ARID2, ATP8A1, ATXN1, BRAF, CCSER2 +13 more
Neutrophils	NF-κB Signaling Inflammatory	ATP13A3, BMP6, DOCK4, DSE, FLT1, IRAK2, KIFC3, MAML2 +2 more

About the gene

Synonyms	HIV-EP2, MBP-2, MIBP1, Schnurri-2, ZAS2, ZNF40B
Chromosome	6: 142751469-142956698
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Function

This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T- cell activation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.