BTLA — B and T lymphocyte associated
BTLA belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BTLA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B cell B cell maturation | ABCB1, ABCB4, C1orf162, CD200, COL19A1, DSP, FCER2, IGHD +15 more | View in SCUBA |
| CD4⁺ T cells | T cell Coinhibition Immune regulation | CASD1, CFAP36, DUSP14, FCHSD2, HIVEP2, IFNGR2, KLF7, NAP1L2 +7 more | View in SCUBA |
About the gene
| Synonyms | BTLA1, CD272 |
|---|---|
| Chromosome | 3: 112463966-112499472 |
| Predicted location | Membrane, Secreted |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
| Biological process | Adaptive immunity, Immunity |
Function
Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.