T cell Coinhibition
Gene co-expression module in CD4⁺ T cells
| Category | Immune regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes include immune signaling regulators: IFNGR2 (interferon-gamma receptor), BTLA (inhibitory coreceptor), DUSP14 (TCR signaling phosphatase), RASA1 (Ras GAP, TCR signaling), KLF7 and HIVEP2 (transcription factors), PIK3CA (signaling), NRARP (Notch). This is a mixed immune-regulation/signaling module enriched in inhibitory receptor (BTLA) and IFNG-responsive components. Strongly upregulated with inflammation in CD. The strongest coherent immunological signature points to a T-cell costimulatory/inhibitory signaling regulation program.
Genes
BTLA, CASD1, CFAP36, DUSP14, FCHSD2, HIVEP2, IFNGR2, KLF7, NAP1L2, NRARP, PIK3CA, POMT1, RASA1, SNN, SUN1, ZFAND1
Most correlated modules
- Vesicle trafficking · correlation 0.89
- DNA damage response · correlation 0.76
- Cellular biosynthesis · correlation 0.74
- TRIM28-ZNF Repression · correlation 0.72
- ER-Golgi Trafficking · correlation 0.67
- Membrane trafficking · correlation 0.65
- IL6-STAT3 Signaling · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.