FCHSD2 — FCH and double SH3 domains 2
FCHSD2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FCHSD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell signaling regulators BCR/AP1/NFKb pathway | AKNA, ATF7IP, DNAJB14, GOLGA4, IKZF3, INPP5D, MYCBP2, PDE7A +3 more | View in SCUBA |
| CD4⁺ T cells | T cell Coinhibition Immune regulation | BTLA, CASD1, CFAP36, DUSP14, HIVEP2, IFNGR2, KLF7, NAP1L2 +7 more | View in SCUBA |
| Gamma-delta T cells | JNK/MAPK Stress Signaling Stress | ABTB3, BICRAL, COP1, DICER1, ELMO1, ERC1, FBXO11, FGFR1 +19 more | |
| Lymphatic endothelial | Cilia Centrosome Program Cytoskeletal | ARB2A, BBS9, BCAS3, CDKAL1, CEP112, EPB41L4A, FTO, MBD5 +7 more | View in SCUBA |
| Macrophages | MITF Lysosomal Program Lysosomal & pahgocytosis | ABHD3, ANKRD44, ARSB, C2CD5, CERS6, CHST11, CNST, DCTN4 +25 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcium Signal Integration TCR Signaling | ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FNDC3A, FOXN3 +20 more | |
| Smooth muscle cells | Lipid Kinase Signaling Housekeeping | ABTB1, ARRDC4, CACNA1H, CBX7, CX3CL1, DGKD, DNTTIP2, FYTTD1 +10 more | View in SCUBA |
About the gene
| Synonyms | KIAA0769, SH3MD3 |
|---|---|
| Chromosome | 11: 72836745-73142318 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Endocytosis, Protein transport, Transport |
Function
Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to- late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate. When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.