EIF4E3 — Eukaryotic translation initiation factor 4E family member 3
EIF4E3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF4E3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Inflammatory effector Immune regulation | C3AR1, CAST, CLDND1, CMTM3, CREB3L2, EPB41, FYCO1, IL18R1 +9 more | View in SCUBA |
| Gamma-delta T cells | Polycomb Transcriptional Control DNA/chromatin regulation | AMFR, ATMIN, BRD7, CBX4, CCNY, CD81, CDK2AP1, CSNK1E +17 more | |
| Monocytes | Pentose Phosphate Pathway Innate immunity | ACAP1, AP5B1, CCDC69, CCND3, CITED4, CORO2A, DYSF, FLOT2 +4 more | View in SCUBA |
About the gene
| Synonyms | MGC39820 |
|---|---|
| Chromosome | 3: 71675414-71754773 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Initiation factor, RNA-binding |
| Biological process | Protein biosynthesis, Translation regulation |
Function
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.