Polycomb Transcriptional Control
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 26 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 26 genes have a known function matching the annotation |
Why this annotation
Hub genes include CBX4 (Polycomb chromobox protein), TADA2B (SAGA histone acetyltransferase complex), BRD7 (bromodomain-containing chromatin regulator), FOXK1 (forkhead transcription factor), MAZ (transcription factor), CSNK1G2 and CSNK1E (casein kinase 1 family, Wnt/circadian signaling), CCNY (cyclin Y, CDK16 partner), PPP2R2D (PP2A regulatory subunit). Strong coherence with core hub members. The module centers on chromatin-associated transcriptional regulation and post-translational control of transcription factors via kinases/phosphatases, neighbor to M58 (chromatin/splicing), supporting a shared transcriptional regulatory network.
Genes
AMFR, ATMIN, BRD7, CBX4, CCNY, CD81, CDK2AP1, CSNK1E, CSNK1G2, EIF4E3, FBRSL1, FOXK1, GRK6, KIAA2013, MAZ, MXD4, PGAP6, PKN1, PPP2R2D, RCC1, RNPEPL1, SLC2A4RG, SREBF1, TADA2B, YTHDF1, ZDHHC18
Most correlated modules
- Chromatin-Splicing Regulation · correlation 0.77
- GPCR-AKT-MAPK Signaling · correlation 0.76
- Innate Stress Signaling · correlation 0.65
- AP-1 Immediate Early Response · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.