BRD7 — Bromodomain containing 7
BRD7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BRD7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Chromatin Cell Cycle DNA/chromatin regulation | ARPP19, CCPG1, CMPK1, IPO9, MBD2, PDS5B, TM9SF2 | View in SCUBA |
| Gamma-delta T cells | Polycomb Transcriptional Control DNA/chromatin regulation | AMFR, ATMIN, CBX4, CCNY, CD81, CDK2AP1, CSNK1E, CSNK1G2 +17 more | |
| Macrophages | RNA Processing & Repair Housekeeping | CCDC59, CCT4, CCT6A, CNDP2, EIF3J, EIF5B, EMC4, EPRS1 +31 more | View in SCUBA |
About the gene
| Synonyms | BP75, CELTIX1, SMARCI1 |
|---|---|
| Chromosome | 16: 50313487-50368988 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Transcription, Transcription regulation, Wnt signaling pathway |
Function
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.