CCNY — Cyclin Y
CCNY belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCNY's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular EC Identity Endothelial cell development | AMOTL1, ARFGEF3, ATN1, CAMK1D, CASP10, CFLAR, F11R, FGD5 +13 more | View in SCUBA |
| Gamma-delta T cells | Polycomb Transcriptional Control DNA/chromatin regulation | AMFR, ATMIN, BRD7, CBX4, CD81, CDK2AP1, CSNK1E, CSNK1G2 +17 more | |
| Pericytes | G1 Cell Cycle Entry Cell cycle | CCND3, CPNE8, FKBP9, GRAMD1A, LIPA, MAPK3, MGAT1, NCK1 +6 more | View in SCUBA |
About the gene
| Synonyms | C10orf9, CBCP1, CFP1 |
|---|---|
| Chromosome | 10: 35247025-35572669 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Cyclin |
| Biological process | Cell cycle, Cell division, Wnt signaling pathway |
Function
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.