EIF4EBP3 — Eukaryotic translation initiation factor 4E binding protein 3
EIF4EBP3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EIF4EBP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Monocyte Identity Innate immunity | C1orf162, CD68, CDK2AP1, CMTM7, DBNDD2, MIF, NME2, TBXAS1 | View in SCUBA |
About the gene
| Synonyms | 4E-BP3 |
|---|---|
| Chromosome | 5: 140547662-140549576 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Protein synthesis inhibitor |
| Biological process | Translation regulation |
Function
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Inhibits EIF4E-mediated mRNA nuclear export.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.