CD68 — CD68 molecule
CD68 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD68's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | MHC-II Antigen Presentation Innate immunity | AIF1, B2M, C1QA, C1QB, C1QC, CD74, CST3, CTSC +19 more | View in SCUBA |
| Monocytes | Monocyte Identity Innate immunity | C1orf162, CDK2AP1, CMTM7, DBNDD2, EIF4EBP3, MIF, NME2, TBXAS1 | View in SCUBA |
About the gene
| Synonyms | DKFZp686M18236, GP110, LAMP4, SCARD1 |
|---|---|
| Chromosome | 17: 7579491-7582111 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
Function
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.