Monocyte Identity
Gene co-expression module in Monocytes
| Category | Innate immunity |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes CD68 (canonical monocyte/macrophage marker), MIF (macrophage migration inhibitory factor, pro-inflammatory cytokine), TBXAS1 (thromboxane synthase, arachidonic acid/eicosanoid metabolism in monocytes), EIF4EBP3 (mTOR-regulated translation), and CMTM7 (chemokine-like transmembrane) collectively define core monocyte identity with lipid mediator production capacity. Core coherence and uniform expression across subsets support a constitutive monocyte program. MIF is a key monocyte-derived inflammatory mediator. TBXAS1 is highly expressed in monocytes and drives thromboxane A2 production.
Genes
C1orf162, CD68, CDK2AP1, CMTM7, DBNDD2, EIF4EBP3, MIF, NME2, TBXAS1
Most correlated modules
- Stress-Adapted Macrophage · correlation 0.77
- Mitochondrial Immune Regulation · correlation 0.74
- Autophagy Metabolic Stress · correlation 0.71
- IL-18 Inflammasome Response · correlation 0.71
- Biosynthetic Metabolic Activation · correlation 0.71
- Non-classical Monocyte · correlation 0.70
- Inflammatory Monocyte Activation · correlation 0.69
- Tissue-Resident Macrophage · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.