ELK1 — ETS transcription factor ELK1
ELK1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ELK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | MMP-driven ECM Remodeling ECM remodeling | A4GALT, ACP5, ASB2, ASMTL, ATP6V0D2, BID, CFP, CPOX +12 more | View in SCUBA |
About the gene
| Chromosome | X: 47635521-47650604 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK and MAPK- signaling pathways stimulation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.