ELMO3 — Engulfment and cell motility 3
ELMO3 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ELMO3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Glycan Precursor Biosynthesis Nutrient processing | ANXA7, APEH, ASL, ATP2A3, CC2D1A, CCDC124, CCND3, CLIC3 +30 more | View in SCUBA |
About the gene
| Synonyms | CED-12, CED12, ELMO-3, FLJ13824 |
|---|---|
| Chromosome | 16: 67199111-67204029 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Apoptosis, Phagocytosis |
Function
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.