CLIC3 — Chloride intracellular channel 3
CLIC3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLIC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Gamma-delta T cell Cell contamination | ABHD15, ANKRD28, APOBR, CLIC5, EGLN3, ELOVL6, GLO1, NBL1 +9 more | View in SCUBA |
| CD8⁺ T cells | Gut Tissue Residency Gut residence | ALOX5AP, C4orf3, CAPN2, CD164, CD3D, CD7, CD99, ID2 +9 more | View in SCUBA |
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | ABI3BP, ADRA2C, ANXA3, CGNL1, ELN, FBLN2, FGF18, GUCY1A1 +5 more | View in SCUBA |
| Mucosal-associated invariant T cell | NK-like Cytotoxic cytotoxicity | AKR1C3, BNC2, CX3CR1, FCGR3A, FGFBP2, GNLY, IGFBP7, KIR3DL1 +3 more |
About the gene
| Chromosome | 9: 136994608-136996568 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Chloride channel, Ion channel, Oxidoreductase, Voltage-gated channel |
| Biological process | Ion transport, Transport |
Function
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding. Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.