APEH — Acylaminoacyl-peptide hydrolase
APEH belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APEH's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Glycolysis & Proteasome Housekeeping | ACAA2, ANAPC15, C1QBP, CCDC167, CHMP2A, CLNS1A, ENO1, HINT1 +11 more | |
| Macrophages | ER Stress UPR Stress | ANKRD9, ARMCX6, BET1L, CALR, CCDC107, COPS2, DNAJB11, DNAJB9 +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Complex Regulation DNA/chromatin regulation | CAPZB, CCND2, CFH, CHTF8, ESYT1, GDI2, HACD4, HCLS1 +9 more |
About the gene
| Synonyms | D3F15S2, D3S48E, DNF15S2 |
|---|---|
| Chromosome | 3: 49674014-49683971 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity). Also, involved in the degradation of oxidized and glycated proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.