Glycan Precursor Biosynthesis
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 39 genes have a known function matching the annotation |
Why this annotation
Hub genes include ASL (argininosuccinate lyase, urea/arginine metabolism), ELMO3 (engulfment and cell motility), NCLN (nicalin, Notch signaling modulator), ATP2A3 (SERCA3, ER Ca2+ pump), APEH (acylpeptide hydrolase, protein catabolism), GNE (UDP-GlcNAc epimerase, sialic acid/glycosylation), GMPPA (GDP-mannose pyrophosphorylase, glycosylation), LPCAT4 (lysophospholipid acyltransferase, membrane remodeling), UQCRC1/NDUFS2 (mitochondrial respiratory chain), CCND3 (cyclin D3, cell cycle), and MPDU1 (mannose-P-dolichol utilization, N-glycosylation). This is a mixed module combining nucleotide sugar/glycosylation biosynthesis, mitochondrial metabolism, and some cell cycle components. The glycosylation biosynthesis theme (GNE, GMPPA, MPDU1, GMDS-neighbor) is the most coherent thread. Moderate disease association, uniform expression. Neighbor to ER/secretory modules, consistent with glycan precursor supply.
Genes
Most correlated modules
- ER Glycoprotein Folding · correlation 0.84
- ER Stress & Lipid Metabolism · correlation 0.81
- Mitochondrial Biogenesis · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.