ATP2A3 — ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
ATP2A3 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATP2A3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin modifiers DNA/chromatin regulation | BIRC6, KDM5A, KMT2C, LPIN1, MBNL1, NCOA3, NFAT5, RBM5 +1 more | View in SCUBA |
| CD4⁺ T cells | Leukocyte Motility migration & adhesion | HSH2D, LRP12, LZTFL1, MYO1G, MYO9B, NBEAL2, PPARG, TBC1D31 +1 more | View in SCUBA |
| Endothelial | Vascular Homeostasis Endothelial cell development | ATP6V1C2, C19orf33, CP, EMP3, ICAM2, MERTK, PLLP, PPP1R14A +5 more | View in SCUBA |
| Gamma-delta T cells | Immune Synapse Cytoskeleton Cytoskeletal | ARHGAP4, ARHGAP45, CD48, DDOST, ICAM3, IL32, LAPTM5, LTB4R2 +8 more | |
| Monocytes | IgA-Monocyte Activation Innate immunity | AATK, AREG, ASPH, CD82, FCAR, NIBAN2, SERPINB2, SLC16A6 +3 more | View in SCUBA |
| Mucosal-associated invariant T cell | Lymphocyte Trafficking migration & adhesion | AASDHPPT, ANXA2, ARL14EP, BIN1, BTN3A2, DGKZ, OSTC, PTP4A2 +8 more | |
| Neutrophils | mRNA Splicing Processing Housekeeping | ABCA13, EMB, FBXO9, LUC7L3, NKTR, OGT, PAXBP1, PNN +8 more |
About the gene
| Synonyms | SERCA3 |
|---|---|
| Chromosome | 17: 3923870-3964464 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins |
| Molecular function | Translocase |
| Biological process | Calcium transport, Ion transport, Transport |
Function
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.