EPOR — Erythropoietin receptor
EPOR belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EPOR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Hematopoietic progenitor cells | Erythroid Differentiation Erythropoietic | DHRS11, DNAJC6, FHL2, GATA1, HBD, KLF1, LXN, MICAL2 +5 more |
About the gene
| Chromosome | 19: 11377207-11384342 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Receptor for erythropoietin, which mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade (By similarity). In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase (By similarity). Acts as a dominant-negative receptor of EPOR-mediated signaling
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.