LXN — Latexin
LXN belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LXN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1 +15 more | View in SCUBA |
| Fibroblasts | Inflammatory ECM Remodeling ECM remodeling | ABRACL, ADAMTS2, CD82, CHI3L1, COTL1, GGCT, MT2A, NID2 +5 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Differentiation Erythropoietic | DHRS11, DNAJC6, EPOR, FHL2, GATA1, HBD, KLF1, MICAL2 +5 more | |
| Pericytes | Actin Cytoskeletal Remodeling Cytoskeletal | CDC42EP1, DPYSL2, ETS1, FMNL3, HDAC1, ORAI2, RAI14, SHC1 | View in SCUBA |
About the gene
| Chromosome | 3: 158645822-158672648 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Heparin-binding, Metalloenzyme inhibitor, Metalloprotease inhibitor, Protease inhibitor |
| Biological process | Inflammatory response |
Function
Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.