Erythroid Differentiation
Gene co-expression module in Hematopoietic progenitor cells
| Category | Erythropoietic |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
This module contains the most canonical erythropoietic genes: HBD (hemoglobin delta chain), EPOR (erythropoietin receptor), GATA1 (master erythroid transcription factor), KLF1 (erythroid Krüppel-like factor critical for terminal erythroid differentiation), TFR2 (transferrin receptor 2, erythroid iron sensing), TPM1 (tropomyosin in erythroid cytoskeleton), LXN (latexin, erythroid progenitor marker). Core coherence and low pct positive (8.7%) consistent with expression restricted to erythroid-committed progenitors. Strongest erythropoietic module in this batch.
Genes
DHRS11, DNAJC6, EPOR, FHL2, GATA1, HBD, KLF1, LXN, MICAL2, MYH10, PKIG, STXBP6, TFR2, TPM1
Most correlated modules
- Erythroid Progenitor Program · correlation 0.87
- Oxidative Stress Survival · correlation 0.87
- Replication Stress Response · correlation 0.86
- Erythro-Megakaryocytic Development · correlation 0.82
- General Metabolic Housekeeping · correlation 0.78
- HSC Progenitor Proliferation · correlation 0.73
- Chromatin Remodeling · correlation 0.73
- HSC Stemness Program · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.