FHL2 — Four and a half LIM domains 2
FHL2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FHL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Chemokine Response Chemotaxis | BMP2, CCL2, CEBPB, CEBPD, CNKSR3, CXCL1, CXCL2, CXCL3 +14 more | View in SCUBA |
| Enterocytes | Colonocyte terminal differentiation Epithelial development | CCDC186, CEACAM1, CMPK1, GCNT3, HKDC1, IFNGR1, LRRFIP1, PTP4A1 +2 more | View in SCUBA |
| Fibroblasts | WNT4+ Stromal Fibroblast Developmental | CARD16, CASP1, FBLIM1, GRK5, IQGAP2, OTULINL, PIEZO2, PROCR +7 more | View in SCUBA |
| Goblet cells | Actin Cytoskeletal Remodeling Cytoskeletal | ACTN4, ACTR3, BHLHE40, CAP1, KCNK1, LRP10, SDCBP, SLC7A11 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythroid Differentiation Erythropoietic | DHRS11, DNAJC6, EPOR, GATA1, HBD, KLF1, LXN, MICAL2 +5 more | |
| Pericytes | Inflammatory ECM Remodeling ECM remodeling | CCDC80, CD44, FMO3, FN1, PDLIM3, RARRES2, TGFBI, TNC +1 more | View in SCUBA |
| Smooth muscle cells | Adhesion Activation Migration & adhesion | ANXA2, ATP1B3, CAPNS1, CD44, CYBRD1, LAMC1, LGALS3, LGALS3BP +3 more | View in SCUBA |
About the gene
| Synonyms | DRAL, SLIM3 |
|---|---|
| Chromosome | 2: 105357712-105438513 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.