ERN2 — Endoplasmic reticulum to nucleus signaling 2
ERN2 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ERN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | ER Stress & Lipid Metabolism Nutrient processing | ACSF3, AP1G2, ARHGEF10L, ASPSCR1, CCDC12, CCDC57, CDC37, CHD3 +27 more | View in SCUBA |
About the gene
| Synonyms | IRE1b |
|---|---|
| Chromosome | 16: 23690310-23713226 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Kinase, Multifunctional enzyme, Serine/threonine-protein kinase, Transferase |
| Biological process | Apoptosis, Transcription, Transcription regulation |
Function
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.