ARHGEF10L — Rho guanine nucleotide exchange factor 10 like
ARHGEF10L belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARHGEF10L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Epithelial polarity cytoskeleton Cytoskeletal | ARID5B, CADPS2, CLMN, DGKH, FAR2, LLGL2, PLEKHA5, PLEKHG1 +3 more | View in SCUBA |
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, AGFG1, ARID5B, ATP2B4, BCL6, CCL13, CD55 +24 more | View in SCUBA |
| Monocytes | MHC II Antigen Presentation Innate immunity | CD4, CD74, HLA-DQA2, HLA-DRB5, RASA4, RTN1, SASH1, SETDB2 | View in SCUBA |
| Smooth muscle cells | FOXC-PRDM16 Program Development | CARNS1, CKMT2, CMKLR1, DUSP26, FOXC1, FOXC2, ITIH3, MYO1D +4 more | View in SCUBA |
About the gene
| Synonyms | FLJ10521, KIAA1626 |
|---|---|
| Chromosome | 1: 17539698-17697874 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.