CHD3 — Chromodomain helicase DNA binding protein 3
CHD3 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHD3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin Regulation DNA/chromatin regulation | ADI1, ASXL2, BTG3, CASP8, CTSS, CWF19L2, DENND2D, DNTTIP2 +17 more | View in SCUBA |
| Endothelial | Integrin-Actin Adhesion migration & adhesion | APP, CTNNA1, DAG1, DOCK6, FKBP9, FMNL3, ITGA9, ITGB1 +6 more | View in SCUBA |
About the gene
| Synonyms | Mi-2a, Mi2-ALPHA, ZFH |
|---|---|
| Chromosome | 17: 7884796-7912760 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, DNA-binding, Hydrolase |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Involved in transcriptional repression as part of the NuRD complex. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.