ER Stress & Lipid Metabolism
Gene co-expression module in Colonocytes
| Category | Nutrient metabolism |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 36 genes have a known function matching the annotation |
Why this annotation
Top hub ERN2 encodes IRE1β, the intestine-specific ER stress sensor of the unfolded protein response (UPR), highly expressed in colonocytes. FASN (fatty acid synthase) and SREBF1 (SREBP-1, master lipid transcription factor) indicate active lipid biosynthesis. ACSF3 is a mitochondrial fatty acid synthesis enzyme. ENGASE processes N-glycans on ER-processed glycoproteins. LTBP4 is a TGF-β latent binding protein. EVPL (envoplakin) is a cornified envelope component. CHD3 and MBD3 are chromatin regulators. NOXO1 is an NADPH oxidase organizer expressed in colonocytes. E2F3 drives cell cycle transcription. SYNE2 anchors the nucleus to the cytoskeleton. The module is heterogeneous but anchored by ERN2/FASN/SREBF1 in a colonocyte-specific ER/lipid metabolic program. The negative delta_treatment_CD signal suggests this program is suppressed by CD treatment.
Genes
Most correlated modules
- RNA Splicing Processing · correlation 0.86
- Transcription-Coupled Splicing · correlation 0.84
- Spliceosome Assembly · correlation 0.84
- Glycan Precursor Biosynthesis · correlation 0.81
- Mitochondrial Biogenesis · correlation 0.81
- Stress RNA Methylation · correlation 0.74
- Crypt Colonocyte Identity · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.