CCDC57 — Coiled-coil domain containing 57
CCDC57 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCDC57's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Metabolic Housekeeping Housekeeping | ACAP1, ANTKMT, ATP6V0E2, B3GAT3, CHN2, CMTM3, DCTD, DGUOK +12 more | |
| Innate lymphoid cells | Actin Cytoskeletal Regulation Cytoskeleton & motility | AQP3, CLPTM1, COTL1, DCAF11, GSN, GYG1, MZT2B, NAA38 +7 more | View in SCUBA |
About the gene
| Synonyms | FLJ00130, FLJ23754 |
|---|---|
| Chromosome | 17: 82101460-82212878 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis. Critical interface between centrosome and microtubule- mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.