CDC37 — Cell division cycle 37, HSP90 cochaperone
CDC37 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDC37's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Vesicle Trafficking Protein processing & ER | AP2M1, ARF1, EWSR1, GHITM, GNB2, LMAN2, PPP2CA, RAB11B +1 more | View in SCUBA |
| Endothelial | IL-27 Receptor Signaling Inflammation | CCND3, HOXB2, IL27RA, KL, MMP15, NDUFA12, SPARCL1, TMEM243 | View in SCUBA |
| Goblet cells | Pyroptosis Stress Response Stress | ADAM15, AURKAIP1, CENPX, COMTD1, DDX39A, EEF1D, GSDMD, INF2 +6 more | View in SCUBA |
| Innate lymphoid cells | Actin Cytoskeleton Dynamics Cytoskeleton & motility | ACTN4, ALDH9A1, APBB1IP, ARHGAP10, CXXC5, FAM136A, FERMT3, FIP1L1 +26 more | View in SCUBA |
| Macrophages | RAS-MAPK Signaling Housekeeping | ARF4, ATG12, CAMTA1, CHMP4B, ETFA, GLA, HMGA1, JAK1 +26 more | View in SCUBA |
| Pericytes | Vascular Junction Adhesion Migration & adhesion | ABHD17A, CCDC85B, ESAM, FYN, HECW2, PREX1, SELENON, SLC44A2 +2 more | View in SCUBA |
About the gene
| Synonyms | P50CDC37 |
|---|---|
| Chromosome | 19: 10391133-10420121 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Chaperone |
Function
Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.