EXO1 — Exonuclease 1
EXO1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EXO1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Replication Stress Checkpoint Cell cycle | ATAD5, BRCA1, CCNE2, CHEK1, DTL, FAM111B, IFI27L1, MCM10 +1 more | View in SCUBA |
About the gene
| Synonyms | HEX1, hExoI |
|---|---|
| Chromosome | 1: 241847967-241895148 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding, Endonuclease, Excision nuclease, Exonuclease, Hydrolase, Nuclease |
| Biological process | DNA damage, DNA excision, DNA repair, Immunity, Meiosis |
Function
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.