Replication Stress Checkpoint
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
CHEK1 (checkpoint kinase 1, S/G2 checkpoint), BRCA1 (DNA damage response, replication fork protection), EXO1 (exonuclease, mismatch repair and resection), CCNE2 (cyclin E2, S-phase entry), DTL (CRL4 ubiquitin ligase adaptor, replication stress response), MCM10 (replication initiation), ATAD5 (RFTS/PCNA unloading), FAM111B (replication fork protection), PKMYT1 (WEE1-related kinase, CDK1 inhibition at G2/M), IFI27L1 (interferon-induced, occasionally co-expressed in cycling/stressed cells). The dominant theme is replication stress and S/G2 checkpoint signaling. The low pct positive (3.1%) suggests this program is active in a small subset of highly proliferating or stressed cells. Neighbor context: sits adjacent to M82 (replication fork) and M78 (MCM loading), forming the checkpoint surveillance arm of the cell cycle program.
Genes
ATAD5, BRCA1, CCNE2, CHEK1, DTL, EXO1, FAM111B, IFI27L1, MCM10, PKMYT1
Most correlated modules
- DNA Replication Fork · correlation 0.96
- S-phase Progression · correlation 0.94
- Replication Licensing · correlation 0.91
- MCM Helicase Loading · correlation 0.89
- Histone Synthesis S-phase · correlation 0.89
- Epigenetic Chromatin Maintenance · correlation 0.88
- G2/M Checkpoint · correlation 0.88
- S-phase Replication · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.