ATAD5 — ATPase family AAA domain containing 5
ATAD5 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATAD5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ATAD2, BRCA1, CDCA4, E2F8, ESCO2, FANCI, FBXO5, LIG1 +4 more | View in SCUBA |
| CD8⁺ T cells | Replication Stress Checkpoint Cell cycle | BRCA1, CCNE2, CHEK1, DTL, EXO1, FAM111B, IFI27L1, MCM10 +1 more | View in SCUBA |
| Endothelial | S-phase Proliferation Cell cycle | ATAD2, BRCA1, BRCA2, CENPH, CENPK, CENPU, DHFR, EZH2 +11 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN, DHFR +13 more | |
| Hematopoietic progenitor cells | S-phase Progression Cell cycle | ATAD2, BRCA2, DNMT1, FANCI, LMNB1, RRM1, SMC2, TMPO +1 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN, DHFR +31 more | View in SCUBA |
About the gene
| Synonyms | C17orf41, ELG1, FLJ12735, FRAG1 |
|---|---|
| Chromosome | 17: 30831966-30895869 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Biological process | DNA damage |
Function
Has an important role in DNA replication and in maintaining genome integrity during replication stress. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damage-induced apoptosis. Promotes PCNA deubiquitination by recruiting the ubiquitin-specific protease 1 (USP1) and WDR48 thereby down-regulating the error-prone damage bypass pathway. As component of the ATAD5 RFC-like complex, regulates the function of the DNA polymerase processivity factor PCNA by unloading the ring-shaped PCNA homotrimer from DNA after replication during the S phase of the cell cycle. This seems to be dependent on its ATPase activity. Plays important roles in restarting stalled replication forks under replication stress, by unloading the PCNA homotrimer from DNA and recruiting RAD51 possibly through an ATR-dependent manner. Ultimately this enables replication fork regression, breakage, and eventual fork restart. Both the PCNA unloading activity and the interaction with WDR48 are required to efficiently recruit RAD51 to stalled replication forks. Promotes the generation of MUS81-mediated single-stranded DNA-associated breaks in response to replication stress, which is an alternative pathway to restart stalled/regressed replication forks.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.