BRCA1 — BRCA1 DNA repair associated
BRCA1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BRCA1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | ATAD2, ATAD5, CDCA4, E2F8, ESCO2, FANCI, FBXO5, LIG1 +4 more | View in SCUBA |
| CD8⁺ T cells | Replication Stress Checkpoint Cell cycle | ATAD5, CCNE2, CHEK1, DTL, EXO1, FAM111B, IFI27L1, MCM10 +1 more | View in SCUBA |
| Endothelial | S-phase Proliferation Cell cycle | ATAD2, ATAD5, BRCA2, CENPH, CENPK, CENPU, DHFR, EZH2 +11 more | View in SCUBA |
| Gamma-delta T cells | DNA Replication Licensing Cell cycle | CHAF1A, HELLS, MCM2, MCM3, MCM4, MCM5, MCM7, PAQR4 +2 more | |
| Goblet cells | S-phase DNA Replication Cell cycle | ASF1B, CDC6, CENPU, DHFR, FEN1, MYBL2, PCLAF, TK1 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Replication Origin Licensing Cell cycle | CDC6, CLSPN, DTL, FAM111B, MCM10, ORC6, WDR76, XRCC2 | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, CENPK, CENPM, CENPU, CLSPN, DHFR +31 more | View in SCUBA |
About the gene
| Synonyms | BRCC1, FANCS, PPP1R53, RNF53 |
|---|---|
| Chromosome | 17: 43044295-43170245 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding, Transferase |
| Biological process | Cell cycle, DNA damage, DNA recombination, DNA repair, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.