MCM10 — Minichromosome maintenance 10 replication initiation factor
MCM10 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MCM10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Replication Stress Checkpoint Cell cycle | ATAD5, BRCA1, CCNE2, CHEK1, DTL, EXO1, FAM111B, IFI27L1 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | Replication Origin Licensing Cell cycle | BRCA1, CDC6, CLSPN, DTL, FAM111B, ORC6, WDR76, XRCC2 |
About the gene
| Synonyms | CNA43, DNA43, PRO2249 |
|---|---|
| Chromosome | 10: 13161558-13211110 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | DNA damage, DNA replication |
Function
Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.