SCUBA

CD8⁺ T cells: gene co-expression modules

Cytotoxic T lymphocytes recognising peptide on MHC class I; release perforin and granzymes to kill infected or transformed cells, and persist as tissue-resident memory in mucosa.

SCUBA's reference network for CD8⁺ T cells holds 89 gene modules covering 1,070 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.

View the CD8⁺ T cells network in SCUBA

Cell cycle (20)

CDK1-Aurora Kinase Mitosis · 11 genes
DNA Replication Fork · 14 genes
FOXM1-driven G2/M · 8 genes
G1/S Entry Checkpoint · 9 genes
G2/M Cell Cycle · 10 genes
G2/M Checkpoint · 10 genes
Histone Synthesis S-phase · 9 genes
MCM Helicase Loading · 14 genes
Mitosis & Cytokinesis · 8 genes
Mitotic Kinase Cascade · 15 genes
Mitotic Spindle · 12 genes
Mitotic Spindle · 15 genes
Mitotic Spindle Assembly · 12 genes
Proliferating CD8 T cell · 9 genes
Replication Licensing · 17 genes
Replication Stress Checkpoint · 10 genes
S-phase Chromatin Replication · 13 genes
S-phase Progression · 14 genes
S-phase Replication · 9 genes
Spindle Bipolarity Cytokinesis · 13 genes

Cytoskeletal (4)

cytotoxicity (2)

Cytotoxic Effector · 13 genes
Cytotoxic Gut Effector · 12 genes

DNA/chromatin regulation (1)

Epigenetic Chromatin Maintenance · 11 genes

Exhaustion (4)

Gut residence (4)

Gut Residence Trm · 13 genes
Gut Tissue Residency · 18 genes
IEL Gut Residence · 10 genes
Tissue residence · 10 genes

Housekeeping (8)

Immune regulation (2)

MHC Class II Presentation · 12 genes
T cell Immune Tolerance · 8 genes

Inflammation (6)

Mitochondrial & OxPhos (5)

Protein processing & ER (4)

RNA processing & translation (11)

Stress (5)

T cell maturation (6)

Tc17 program (2)

Tc17 program · 13 genes
Tc17 Survival Program · 8 genes

TCR Signaling (5)