FAM20B — FAM20B glycosaminoglycan xylosylkinase
FAM20B belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FAM20B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | SMC Phenotype Regulation Development | ARHGAP42, BMPR2, CTXN1, EFR3A, HACD4, INPP5A, OSBPL1A, RCSD1 +5 more | View in SCUBA |
About the gene
| Synonyms | GXK1, KIAA0475 |
|---|---|
| Chromosome | 1: 179025804-179076567 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Transferase |
Function
Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O- phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT- I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.