BMPR2 — Bone morphogenetic protein receptor type 2
BMPR2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BMPR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IL-13/STAT6 Signaling Inflammation | ABLIM1, ARL2BP, ASRGL1, ATP8B1, BMP1, CLIP1, CMIP, EHBP1L1 +18 more | View in SCUBA |
| Gamma-delta T cells | Osmotic Stress Response Stress | BAZ1A, HIPK3, HTT, LIX1L, MAPRE2, NFAT5, RALGAPB, RTN4 +6 more | |
| Pericytes | BMP Receptor Signaling Developmental | CRK, LRRC8C, PLEKHG1, PTPRN2, RBMS2, RPS6KA2, SNAP23, TMEM181 +1 more | View in SCUBA |
| Smooth muscle cells | SMC Phenotype Regulation Development | ARHGAP42, CTXN1, EFR3A, FAM20B, HACD4, INPP5A, OSBPL1A, RCSD1 +5 more | View in SCUBA |
About the gene
| Synonyms | BMPR-II, BMPR3, BRK-3, PPH1, T-ALK |
|---|---|
| Chromosome | 2: 202376327-202567751 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins |
| Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6. Promotes signaling also by binding to activin A/INHBA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.