INPP5A — Inositol polyphosphate-5-phosphatase A
INPP5A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
INPP5A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Actomyosin Contractility Cytoskeletal | BCAP29, CAPN2, GNB2, ITPRIPL2, LGALS1, LRRC8C, MPRIP, NID1 +2 more | View in SCUBA |
| Neutrophils | PI3K Chemotaxis Signaling Chemotaxis | ABCA1, ACSL1, ALDH1A2, CRK, LIMK2, NUP98, PIK3R5, PTPN12 +6 more | |
| Smooth muscle cells | SMC Phenotype Regulation Development | ARHGAP42, BMPR2, CTXN1, EFR3A, FAM20B, HACD4, OSBPL1A, RCSD1 +5 more | View in SCUBA |
About the gene
| Synonyms | 5PTASE |
|---|---|
| Chromosome | 10: 132537787-132783480 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate. Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.