OSBPL1A — Oxysterol binding protein like 1A
OSBPL1A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OSBPL1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CA4, CABP1, CD36, FABP5, FMNL2, IGFBP6, ISLR, LNX1 +6 more | View in SCUBA |
| Macrophages | DNA Damage Repair Stress | ABCC5, ADAM28, AKAP9, AKNA, ATM, ATP10D, BAZ2A, CHD9 +27 more | View in SCUBA |
| Smooth muscle cells | SMC Phenotype Regulation Development | ARHGAP42, BMPR2, CTXN1, EFR3A, FAM20B, HACD4, INPP5A, RCSD1 +5 more | View in SCUBA |
About the gene
| Synonyms | ORP-1, ORP1, OSBPL1B |
|---|---|
| Chromosome | 18: 24162045-24397880 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Lipid transport, Transport |
Function
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.