FASN — Fatty acid synthase
FASN belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FASN's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | ER Stress & Lipid Metabolism Nutrient processing | ACSF3, AP1G2, ARHGEF10L, ASPSCR1, CCDC12, CCDC57, CDC37, CHD3 +27 more | View in SCUBA |
About the gene
| Synonyms | FAS, SDR27X1 |
|---|---|
| Chromosome | 17: 82078338-82098294 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Hydrolase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Function
Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.