FCGR1A — Fc gamma receptor Ia
FCGR1A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FCGR1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Fc Receptor Phagocytosis Lysosomal & pahgocytosis | ANXA6, C1orf162, CD37, FCGR3A, FPR1, GCA, HNMT, HTRA1 +10 more | View in SCUBA |
| Monocytes | IFN-gamma Monocyte Activation Inflammatory | BLVRA, CYB5A, DRAP1, GAS6, HLA-F, IFITM3, LGALS9, LILRB1 +3 more | View in SCUBA |
About the gene
| Synonyms | CD64, CD64A, FCG1, FcgammaRI, FcgammaRIa, FCGR1 |
|---|---|
| Chromosome | 1: 149782671-149791675 |
| Predicted location | Membrane |
| Essential gene | Yes |
| Protein class | CD markers, Essential proteins, FDA approved drug targets, Predicted membrane proteins |
| Molecular function | IgG-binding protein, Receptor |
| Biological process | Immunity, Innate immunity |
Function
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.