FPR1 — Formyl peptide receptor 1
FPR1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FPR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Fc Receptor Phagocytosis Lysosomal & pahgocytosis | ANXA6, C1orf162, CD37, FCGR1A, FCGR3A, GCA, HNMT, HTRA1 +10 more | View in SCUBA |
| Monocytes | FPR1 Innate Sensing Innate immunity | CD300LF, FYN, OSCAR, SELPLG, SIRPB1, SLC11A1, SULF2, SYTL1 +1 more | View in SCUBA |
| Neutrophils | Myeloid Inflammatory Activation Inflammatory | AQP9, CPD, ITGAX, LITAF, MXD1, NABP1, NAMPT, SDCBP +5 more |
About the gene
| Synonyms | FMLP, FPR |
|---|---|
| Chromosome | 19: 51745172-51804115 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Chemotaxis |
Function
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.