SCUBA

ANXA6 — Annexin A6

ANXA6 belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ANXA6's module in each cell type

Cell typeModuleShares the module with
CD8⁺ T cellsTumor mediated exhaustion
Exhaustion
CXCL13, GALM, HNRNPLL, IFNG, ITM2A, PDCD1, PTPN7, SARDH +3 moreView in SCUBA
EndothelialInflammatory Endothelial Activation
Inflammation
CNIH1, COTL1, DEGS1, DHRS7, F2R, FKBP10, FSTL1, JAK1 +8 moreView in SCUBA
FibroblastsRho-ROCK Contractility
Cytoskeletal
ATP2B4, CBX6, CSDE1, DYNLT3, GNG12, ITM2C, PPP1CB, ROCK1 +1 moreView in SCUBA
Gamma-delta T cellsButyrophilin gd Activation
TCR Signaling
ABI1, ADD3, ARHGAP1, ARHGAP25, ARHGAP30, ARHGEF2, BTN3A1, BTN3A3 +16 more
Innate lymphoid cellsMitochondrial OxPhos
Mitochondrial & OxPhos
AKR7A2, AP2M1, ARL6IP4, ARPC1B, ATP5MC2, ATP5PB, BSG, CCNDBP1 +21 moreView in SCUBA
MacrophagesFc Receptor Phagocytosis
Lysosomal & pahgocytosis
C1orf162, CD37, FCGR1A, FCGR3A, FPR1, GCA, HNMT, HTRA1 +10 moreView in SCUBA
MonocytesClassical Monocyte Trafficking
Migration & adhesion
CKAP4, EMB, F5, GCA, MAP2K6, MPP7, MSRB1, PADI4 +4 moreView in SCUBA
Mucosal-associated invariant T cellActin Cytoskeletal Remodeling
Cytoskeletal
CAP1, CASP1, CCT5, CCT6A, DEF6, FGD3, GIMAP6, HNRNPF +7 more
Natural Killer cellsActin Cytoskeleton Remodeling
Cytoskeleton & motility
ARPC1B, ARPC4, BAX, CAPNS1, CAPZB, GNAI2, IL2RG, NDUFA13 +7 moreView in SCUBA
Smooth muscle cellsSMC focal adhesion
Migration & adhesion
ARMCX6, C1orf21, CD99, DNAJC1, HSBP1, KANK1, MORF4L2, PFDN1 +7 moreView in SCUBA

About the gene

SynonymsANX6
Chromosome5: 151100706-151157815
Predicted locationIntracellular
Essential geneNo
Protein classPlasma proteins, Predicted intracellular proteins, Transporters

Function

May associate with CD21. May regulate the release of Ca(2+) from intracellular stores

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.