HNMT — Histamine N-methyltransferase
HNMT belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HNMT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Crypt CFTR secretion Secretion | ACACA, CFTR, DACH1, EIF4G3, EML4, MBOAT1, PLCE1, SULT1E1 +1 more | View in SCUBA |
| Macrophages | Fc Receptor Phagocytosis Lysosomal & pahgocytosis | ANXA6, C1orf162, CD37, FCGR1A, FCGR3A, FPR1, GCA, HTRA1 +10 more | View in SCUBA |
About the gene
| Chromosome | 2: 137964020-138016364 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
Function
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.